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Based on the genome sequence and protein expression levels of human epidermal growth factor 2 (HER2), progesterone receptor (PR) and estrogen receptor (ER), breast cancer can be divided into luminal, HER2-enriched and triple-negative types (2)

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This, consequently, inhibits the mTOR pathway and triggers the autophagic degradation of the oncogenic transcription factor TCF3 [99]